Dosing frequency

Getting started with TARGRETIN

Gel dosing1

Initially, TARGRETIN Gel should be applied directly on affected areas once every other day. Depending on efficacy and tolerability, application frequency may be increased.

Week 1 Calendar = 1x per DayWeek 1 Calendar = 1x per Day

TARGRETIN Gel should be applied once daily every other day for the first week.

Week 2 Calendar = 1x per Day Week 2 Calendar = 1x per Day

TARGRETIN Gel should be applied once daily for the second week.

Week 3 Calendar = 2x per Day Week 3 Calendar = 2x per Day

TARGRETIN Gel should be applied twice daily for the third week.

Week 4 Calendar = 3x per Day Week 4 Calendar = 3x per Day

TARGRETIN Gel should be applied three times daily for the fourth week.

Week 5 Calendar = 4x per Day Week 5 Calendar = 4x per Day

TARGRETIN Gel should be applied four times daily for the fifth week.

If application site toxicity occurs, the application frequency can be reduced. Should severe irritation occur, application of drug can be temporarily discontinued for a few days until symptoms subside.

Minimal application hazards1

Patients do not have to wear gloves while applying TARGRETIN Gel.

No Gloves Required
No gloves required
No Refrigeration Required
No refrigeration required
Keep away from heat or flame
Keep away from heat or flame

Capsule dosing2

The initial recommended dose of TARGRETIN is 300 mg/m2/day, taken as a single oral daily dose with a meal.

low high
Body surface area:

of affected skin patches


Number of 75mg


Total daily dose


If TARGRETIN Capsules are not tolerated, the 300 mg/m2/day dose level may be adjusted to 200 mg/m2/day then 100 mg/m2/day, or temporarily suspended.

If initial dose is well tolerated with no tumor response after 8 weeks of treatment, the dose may be increased to 400 mg/m2/day with careful monitoring.


Important safety information

Indication and usage

TARGRETIN® (bexarotene) capsules and gel are indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma (only stages 1A and 1B for gel) in patients who are refractory to at least one prior systemic therapy.

Important Safety Information

Birth defects

Because of the risk of fetal harm, TARGRETIN capsules and gel must not be given to a woman who is pregnant or who intends to become pregnant. If a woman becomes pregnant during treatment with TARGRETIN, treatment must be stopped immediately, and the woman provided appropriate counseling about the risks.

To prevent pregnancy, effective contraception must be used for one month prior to the initiation of TARGRETIN therapy, during therapy and for at least one month following discontinuation of therapy; it is recommended that two reliable forms of contraception be used simultaneously unless abstinence is the chosen method. Male patients with sexual partners who are pregnant, possibly pregnant or who could become pregnant must use condoms during treatment and for at least one month after the last dose of drug.

No more than a one month supply of TARGRETIN should be given to the patient so that the results of pregnancy testing can be assessed and counseling regarding avoidance of pregnancy and birth defects can be reinforced.


TARGRETIN capsules and gel are contraindicated in patients with a known serious hypersensitivity to bexarotene or other components of the product.

Warnings and precautions

Hyperlipidemia is present in most patients treated with TARGRETIN capsules. Obtain baseline values, monitor during treatment, and manage elevations during therapy.

Acute pancreatitis, including a fatal case, has been reported in patients treated with TARGRETIN capsules. Interrupt treatment and evaluate if suspected.

Hepatotoxicity, cholestasis, and hepatic failure TARGRETIN capsules had a dose-related effect on liver chemistry tests in clinical trials, including incidence of cholestasis and liver failure.

Hypothyroidism TARGRETIN capsules induce hypothyroidism in about half of all patients; obtain baseline thyroid function tests and monitor patients during treatment.

Neutropenia Leukopenia and neutropenia occurred in clinical trials with TARGRETIN capsules; obtain complete blood counts at baseline and periodically during treatment.

Cataracts Although a causal relationship has not been established, cataracts have been observed in animal and clinical studies with TARGRETIN capsules. Refer patients who experience visual difficulties for ophthalmologic evaluation.

Hypoglycemia in Diabetes TARGRETIN capsules may cause hypoglycemia in patients using insulin, agents enhancing insulin secretions, or insulin-sensitizers.

Nursing: Discontinue nursing during treatment with TARGRETIN.

Laboratory tests including CBC, fasting lipid profile, liver function tests, and thyroid profile should be obtained prior to treatment.

CA125 assay values in ovarian cancer patients may be elevated by treatment.

Capsules and Gel

Vitamin A Patients should be advised to limit Vitamin A intake to avoid potential additive toxicity.

Photosensitivity Advise patients to minimize exposure to sun and artificial sunlight during treatment.


Patients who are applying TARGRETIN gel should not concurrently use products that contain DEET, a common component of insect repellent products.

For nursing women, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

Adverse reactions

The most common adverse reactions (>10%) include hyperlipidemia, hypercholesteremia, headache, hypothyroidism, asthenia, leukopenia, rash, nausea, infection, peripheral edema, abdominal pain, and dry skin.


The most common adverse events reported in TARGRETIN gel clinical trials with an incidence at the application site of at least 10% were: rash, pruritus, skin disorder, and pain.

To report SUSPECTED ADVERSE REACTIONS contact customer service at 1-800-321-4576 or FDA at 1-800-FDA-1088 or visit

Click here for full Prescribing Information, including Boxed Warning for TARGRETIN capsules.

Click here for full Prescribing information for TARGRETIN gel.

  1. TARGRETIN gel 1% [prescribing information]. Bridgewater, NJ: Bausch Health US, LLC.
  2. TARGRETIN 75 mg capsules [prescribing information]. Bridgewater, NJ: Bausch Health US, LLC.